![]() ![]() But a lot of research has shown that about 15 to 30 percent of genes “escape” X chromosome inactivation in females and are active from both X chromosomes. ![]() Superficially, this implies that it doesn't matter if you have two X’s or one you basically only have one that's active. In order to equalize gene levels between females with two X’s and males with one X, a process called X chromosome inactivation effectively turns off one of the X’s. Similarly, there are misconceptions about the X chromosome that have led to it being overlooked. We think that differences in activity between the X and Y versions of these genes could lead to sex differences. The latter group is of particular interest because these genes have counterparts on the X chromosome. One group of Y genes is required for male fertility and another group participates in fundamental cellular processes throughout the body. However, the Page lab and others have discovered that there are many more important functions for the Y chromosome. The Y chromosome has a false reputation of being a genetic wasteland with only one job: to act as a switch that decides whether a developing embryo will form ovaries or testes. In my research, I’m asking the question, does a cell with two X chromosomes look or act differently than a cell with an X and a Y chromosome?Ĭould you expand on why an XX cell might be different than an XY cell?Ī lot of people pay attention to the role of sex hormones in differences between males and females, which is certainly important however, the role of the sex chromosomes have been overlooked. I’m trying to understand whether genetic differences between typical females, who have two X chromosomes, and typical males, who have one X and one Y chromosome, result in fundamental biological differences at the level of the cell. For example, autoimmune diseases are much more prevalent in women while cardiovascular diseases tend to be more prevalent in men, but we don’t know why these differences occur. In the Page lab, we’re interested in why there are large differences in health and disease between males and females. ![]() We sat down with San Roman to learn more about her and her experiences in and out of the lab. Brill and Carol Tobin Brill Postdoctoral Fellowship and an NIH Postdoctoral Fellowship. San Roman’s work is supported by the Arthur W. “As a member of Stony Brook Medicine, I have the honor to continue to provide complete personalized Ob-Gyn services in my Port Jefferson Station office and three local hospitals,” he added.Adrianna San Roman is a postdoc in Whitehead Institute Director and Member David Page’s lab investigating sex differences in human health. In fact, I am now taking care of the next generation of women whose births I attended many years ago.” “With this in mind, I have helped to build many strong families in our community. I have built a practice based on the concept of providing excellent and personalized Ob-Gyn care,” said San Roman. “I am very excited to be back at Stony Brook University Hospital. Argen Medical has been providing expert, comprehensive care to women of all ages in the community for more than 30 years. Stony Brook Medicine welcomes private practices that are committed not only to the community but to providing the highest level of quality care. “He has been an outstanding Ob-Gyn in the community and a wonderful proponent of women’s health.” Todd Griffin, chair, Department of Obstetrics, Gynecology and Reproductive Medicine, Stony Brook Medicine. Gustavo San Roman is joining the Stony Brook family,” said Dr. The medical group practices obstetrics and gynecology in Port Jefferson Station. Argen Medical recently joined Stony Brook Community Medical, Stony Brook Medicine’s expanding network of community practices and physicians.
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